Neurotensin Receptor
The neuropeptide neurotensin (NT) exerts central actionsthat include hypothermia, analgesia, and a number of effects that involve the modulation of nigrostriatal and mesocortico-limbic dopaminergic pathways. The two neurotensin receptor subtypes known to date, NTR1 and NTR2, belong to the family of G-protein-coupled receptors with seven putative transmembrane domains (TM). The NTR1 has high affinity for neurotensin, whereas the NTR2 has lower affinity for the peptide and is selectively recognized by levocabastine, an anti-histamine H1 receptor antagonist. These receptors have widespread, though not identical, central and peripheral distributions and exhibit distinct ontogenic profiles.
It is notably reported that NTR1 activation results in significant antinociception but also causes marked hypotension and hypothermia. In sharp contrast, NTR2 has emerged as an important pain target because NTR2-selective analogues exhibit potent analgesic activity in both acute and chronic pain conditions in dose-dependent analgesic effects without inducing drop in blood pressure or body temperature.
Neurotensin Receptor Isoform Specific Products
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Neurotensin Receptor Inhibitors
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Neurotensin Receptor Agonists
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Neurotensin Receptor Antagonists
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Neurotensin Receptor Activators
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Neurotensin Receptor Modulators
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Neurotensin Receptor Ligand
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Neurotensin Receptor Related Products (76)
Related Products (76)
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Antibodies (1)
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Neurotensin Receptor Isoform Comparison
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SORT-PGRN interaction inhibitor 2
0 ImagesCat. No.: HY-153687CAS No.: 1008233-79-1SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research.
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VGD071
0 ImagesCat. No.: HY-139668CAS No.: 2826992-31-6VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models.
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VGD020
0 ImagesCat. No.: HY-182674CAS No.: 1322645-32-8VGD020 is a highly potent and selective Sec61 translocon inhibitor. VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer.
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Fmoc-DL-Leu-OH
0 ImagesFmoc-DL-Leu-OH acts as a partial agonist of the neurotensin NTS1 receptor (NTS1R) with an EC50 of 215.50 μM. Fmoc-DL-Leu-OH triggers intracellular calcium mobilization, and its activity is blocked by selective NTS1R antagonists. Fmoc-DL-Leu-OH can be used in the research of schizophrenia.
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[D-Trp11]-Neurotensin
![[D-Trp11]-Neurotensin](https://file.medchemexpress.com/product_pic/hy-p3057.gif "Click to View [D-Trp11]-Neurotensin Product Detail")
0 ImagesCat. No.: HY-P3057CAS No.: 73634-68-1[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
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Neurotensin(8-13) TFA
0 ImagesCat. No.: HY-P0251ACAS No.: 2952825-79-3Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.
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Ntsr1 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09640Ntsr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntsr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Xenin-8
0 ImagesCat. No.: HY-P1257CAS No.: 117442-28-1Xenin-8 is the C-terminal octapeptide fragment of xenin, which belongs to the xenopsin family of peptides. Xenin-8 stimulates basal insulin secretion, dose-dependently enhances glucose (EC50 = 0.16 nM) and arginine-induced insulin release, and enhances arginine- and Carbamoylcholine chloride (HY-B1208)-induced glucagon secretion. Xenin-8 antagonizes the inhibition of glucagon release by elevated glucose. Xenin-8 can be used in research on type 2 diabetes and obesity-related glucose metabolic disorders.
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SORT1-IN-3
0 ImagesCat. No.: HY-159876CAS No.: 2915675-56-6SORT1-IN-3 (compound 5) is a blood-brain barrier permeable SORT1 inhibitor.
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SR-12062
0 ImagesCat. No.: HY-182551CAS No.: 1623019-77-1SR-12062 is a Neurotensin receptor 1 (NTSR1) full agonist that modulates NTSR1 to trigger intracellular Ca2+ mobilization. SR-12062 can be used for the research of schizophrenia, parkinson’s disease, drug addiction.
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SORT1-IN-1
0 ImagesCat. No.: HY-159868CAS No.: 2806762-69-4SORT1-IN-1 (compound 2) is a SORT1 inhibitor.
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Cyclo (Arg-Lys-Pro-Tyr-Tle-Leu)
0 ImagesCat. No.: HY-P11813CAS No.: 160662-30-6Cyclo (Arg-Lys-Pro-Tyr-Tle-Leu) is a cyclic peptide. Cyclo (Arg-Lys-Pro-Tyr-Tle-Leu) shows extremely low affinity for rat NTS1 expressed in cells (pKi < 4), whereas its semi-purified sample (Batch 2) exhibits moderate affinity for NTS1 (pKi = 5.83), a phenomenon attributed to contamination by an active linear peptide variant. Cyclo (Arg-Lys-Pro-Tyr-Tle-Leu) can be used in research on neurological diseases.
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(S)-Osanetant
0 ImagesSynonyms: (S)-SR142801(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
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SORT1-IN-5
0 ImagesCat. No.: HY-159878CAS No.: 3031580-91-0SORT1-IN-5 (compound 3) is a blood-brain barrier permeable SORT1 inhibitor. SORT1-IN-5 is an MSOH salt with limited oral bioavailability.
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Ntsr2 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09642Ntsr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntsr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Ntsr2 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09643Ntsr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntsr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Xenin-8 acetate
0 ImagesCat. No.: HY-P1257BXenin-8 acetate is the C-terminal octapeptide fragment of xenin, which belongs to the xenopsin family of peptides. Xenin-8 acetate stimulates basal insulin secretion, dose-dependently enhances glucose (EC50 = 0.16 nM) and arginine-induced insulin release, and enhances arginine- and Carbamoylcholine chloride (HY-B1208)-induced glucagon secretion. Xenin-8 acetate antagonizes the inhibition of glucagon release by elevated glucose. Xenin-8 acetate can be used in research on type 2 diabetes and obesity-related glucose metabolic disorders.
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Contulakin G
0 ImagesCat. No.: HY-P0066CAS No.: 229180-41-0Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent.
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hNTS1R agonist-1
0 ImagesCat. No.: HY-149941hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent.
